Base de dados : HANSEN Pesquisa : FATOR DE NECROSE TUMORAL/METAB [Descritor de assunto] Referências encontradas : 6 [refinar] Mostrando: 1 .. 6   no formato [Detalhado]

página 1 de 1

1 / 6

HANSEN

seleciona para imprimir

Id: 18946 Autor: Teles, Rosane M. B; Moraes, Milton O; Geraldo, Natasha T. R; Salles, Ana M; Sarno, Euzenir N; Sampaio, Elizabeth P Título: Differential TNFalpha mRNA regulation detected in the epidermis of leprosy patients ..- Fonte: s.l; s.n; 2002. 8 p. ilus, tab, graf. Resumo: The epidermis is an important site of the immunoinflammatory response in the skin. In the present study, the expression of cytokine and ICAM-1 (intercellular adhesion molecule-1) genes was evaluated by RT-PCR in the epidermis isolated from biopsies from 25 reactional leprosy patients. TNFalpha and IL-6 mRNAs were detected in all individuals during the reactional state (reversal reaction or erythema nodosum leprosum), IL-8 message was detected in 66.6 per cent and 62.5 per cent of the patients, IL-12 mRNA was present in 91.6 per cent and 62.5 per cent and ICAM-1 in 100 per cent and 71.4 per cent, respectively. In addition, when skin biopsies were obtained from the same patients before and during the reactional episode, an enhancement in cytokine mRNA, but not in ICAM-1 mRNA, was observed. Seven patients were also evaluated at the onset of reaction and during antiinflammatory treatment. In contrast to a preferential decrease in the TNFalpha gene detected in the dermis, during the treatment phase, persistent/enhanced TNFalpha mRNA expression was detected in the epidermis in six out of the seven patients assessed. This peculiar pattern of expression might reflect a differential impact that in vivo antiinflammatory therapy has on the epidermis. The present findings indicate that the epidermis plays an important role in the local inflammatory response in leprosy and that the profile of response detected in the epidermis during the reactions may be regulated differently from that in the dermis. (AU). Descritores: CITOCINAS/genet CITOCINAS/metab ANTIINFLAMATORIOS ESTERÓIDES/uso terap DERME/metab HANSENOSTATICOS/uso terap EPIDERME/metab MOLECULA 1 DE ADESAO INTERCELULAR/genet MOLECULA 1 DE ADESAO INTERCELULAR/metab HANSENIASE/quimioter HANSENIASE/metab PENTOXIFILINA/uso terap ANTIINFLAMATORIOS/uso terap RNA MENSAGEIRO/metab TALIDOMIDA/uso terap PREDNISONA/uso terap FATOR DE NECROSE TUMORAL/genet FATOR DE NECROSE TUMORAL/metab Limites: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 09157/s

2 / 6

HANSEN

seleciona para imprimir

Id: 18936 Autor: Vescovo, Giorgio; Ravara, Barbara; Angelini, Annalisa; Sandri, Marco; Carraro, Ugo; Ceconi, Claudio; Dalla Libera, Luciano Título: Effect of thalidomide on the skeletal muscle in experimental heart failure ..- Fonte: s.l; s.n; 2002. 6 p. ilus, tab. Resumo: BACKGROUND: Tumour Necrosis Factor alpha (TNFalpha) has been shown to contribute to heart failure (CHF) progression. AIMS: We have tried to antagonise the detrimental effects of TNFalpha on skeletal muscle apoptosis, by using thalidomide, a drug that inhibits its biosynthesis. METHODS: CHF was induced in 20 rats by injecting monocrotaline, which determines right ventricle (RV) failure. After 2 weeks, when CHF developed, 12 rats were treated with thalidomide 3.5.mg/kg per day for 2 weeks. Eight had saline and served as CHF controls. RESULTS: Thalidomide failed to decrease TNFalpha and its second messenger sphingosine (SPH), but was able to prevent the shift toward the fast myosin heavy chains. In the Tibialis Anterior muscle of the thalidomide group, the degree of atrophy, the number of apoptotic nuclei and the levels of caspases, were similar to those of the CHF controls. CONCLUSIONS: Thalidomide, at the doses used in this study, which are the same employed for the treatment of tubercolosis, leprosy, AIDS and cancer in humans, did not lower either TNFalpha or SPH and only marginally influenced the apoptosis-induced muscle atrophy. Since other TNFalpha blockers are under investigation for improving the clinical status of patients with CHF, the present data could be relevant in the design of randomised clinical trials in humans. (AU). Descritores: APOPTOSE/ef drogas INSUFICIÊNCIA CARDIACA CONGESTIVA/ind quim INSUFICIÊNCIA CARDIACA CONGESTIVA/patol MONOCROTALINA/tox MUSCULO ESQUELETICO/ef drogas MUSCULO ESQUELETICO/patol ATROFIA MUSCULAR/ind quim ATROFIA MUSCULAR/patol CADEIAS PESADAS DE MIOSINA/metab RATOS SPRAGUE-DAWLEY ESFINGOSINA/antag ESFINGOSINA/metab TALIDOMIDA/farmacol FATOR DE NECROSE TUMORAL/antag FATOR DE NECROSE TUMORAL/metab DISFUNCAO VENTRICULAR DIREITA/ind quim DISFUNCAO VENTRICULAR DIREITA/patol Limites: ANIMAL RATOS Meio Eletrônico: - . Localização: BR191.1; 09104/s

3 / 6

HANSEN

seleciona para imprimir

Id: 18472 Autor: Teo, Steve K; Resztak, Ken E; Scheffler, Michael A; Kook, Karin A; Zeldis, Jerry B; Stirling, David I; Thomas, Steve D Título: Thalidomide in the treatment of leprosy ..- Fonte: s.l; s.n; 2002. 10 p. ilus, tab. Resumo: Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-alpha produced by monocytes. (AU). Descritores: QUIMIOTERAPIA COMBINADA ERITEMA NODOSO/quimioter ERITEMA NODOSO/patol INCIDÊNCIA HANSENOSTATICOS/uso terap HANSENIASE/quimioter HANSENIASE/patol HANSENIASE/transm HANSENIASE VIRCHOWIANA/quimioter HANSENIASE VIRCHOWIANA/patol MODELOS MOLECULARES MYCOBACTERIUM LEPRAE/patogen TALIDOMIDA/ef adv TALIDOMIDA/farmacol TALIDOMIDA/farmacocin TALIDOMIDA/uso terap FATOR DE NECROSE TUMORAL/metab Limites: HUMANO Meio Eletrônico: - . Localização: BR191.1; 09014/s

4 / 6

HANSEN

seleciona para imprimir

Id: 15035 Autor: Partida-Sanchez, S; Favila-Castillo, L; Pedraza-Sanchez, S; Gomez-Melgar, M; Saul, A; Estrada-Parra, S; Estrada-Garcia, I Título: IgG antibody subclasses, tumor necrosis factor and IFN-gamma levels in patients with type II lepra reaction in thalidomide treatment ..- Fonte: s.l; s.n; 1998. 7 p. tab, graf. Descritores: ADOLESCENCIA ANTICORPOS ANTIBACTÉRIAS ANTICORPOS ANTIBACTÉRIAS INTERPRETAÇAO ESTATISTICA DE DADOS ERITEMA NODOSO INTERFERON TIPO II INTERFERON TIPO II LEPROSTATICOS LEPROSTATICOS LEPROSTATICOS HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE TALIDOMIDA TALIDOMIDA TALIDOMIDA FATOR DE NECROSE TUMORAL/ME IMUNOGLOBULINA M/BL/CL FATOR DE NECROSE TUMORAL/*ME Limites: ESTUDO COMPARATIVO Localização: BR191.1; 07285/s

5 / 6

HANSEN

seleciona para imprimir

Id: 15023 Autor: Moubasher, Alaa El-Din A; Kamel, Neveen A; Zedan, Hatem; Raheem, Diaa El-Din Abdel Título: Cytokines in leprosy, I. Serum cytokine profile in leprosy ..- Fonte: s.l; s.n; 1998. 8 p. tab, graf. Descritores: CITOCINAS INTERFERON TIPO II INTERLEUCINA-1 INTERLEUCINA-10 INTERLEUCINA-2 HANSENIASE HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE RECEPTORES DA INTERLEUCINA 2 RECEPTORES DA INTERLEUCINA-2/BL FATOR DE NECROSE TUMORAL/ME Limites: ESTUDO COMPARATIVO Localização: BR191.1; 07297/s

6 / 6

HANSEN

seleciona para imprimir

Id: 13689 Autor: Sampaio, Elizabeth P; Kaplan, Gilla; Miranda, Alice; Nery, Jose A. C; Miguel, Consuelo P; Viana, Sergio M; Sarno, Euzenir N Título: The influence of thalidomide on the clinical and immunologic manifestation of eryhtema nodosum leprosum ..- Fonte: s.l; s.n; 1993. 6 p. ilus, tab, graf. Descritores: ERITEMA NODOSO ERITEMA NODOSO HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA TALIDOMIDA FATOR DE NECROSE TUMORAL/ME Localização: BR191.1; 06659/s

---

página 1 de 1

Refinar a pesquisa

Base de dados : HANSEN

Formulário avançado

Pesquisar por : Formulário livre

		Pesquisar	no campo
1			PalavrasPalavras do títuloPalavras do resumoAutorAutor institucionalDescritor de assuntoLimitesIdiomaPaís, ano de publicaçãoRevistaTipo de literaturaNível bibliográficoMonografia em sérieTipo de publicaçãoConferênciaIdentificador únicoLocalizaçãoSuporte eletrônicoData de entradaTipo de registro
2	and or and not		PalavrasPalavras do títuloPalavras do resumoAutorAutor institucionalDescritor de assuntoLimitesIdiomaPaís, ano de publicaçãoRevistaTipo de literaturaNível bibliográficoMonografia em sérieTipo de publicaçãoConferênciaIdentificador únicoLocalizaçãoSuporte eletrônicoData de entradaTipo de registro
3	and or and not		PalavrasPalavras do títuloPalavras do resumoAutorAutor institucionalDescritor de assuntoLimitesIdiomaPaís, ano de publicaçãoRevistaTipo de literaturaNível bibliográficoMonografia em sérieTipo de publicaçãoConferênciaIdentificador únicoLocalizaçãoSuporte eletrônicoData de entradaTipo de registro

Search engine: iAH v2.6.1 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information